
P = Population of interest (consider age, gender, race, ethnicity, disease process, comorbidities)
I = Intervention (exposure to disease, prognostic factor A, risk behaviors, treatment, what do you want to do for this population? what could be done better?)
C = Comparison of interest (no comparison, placebo, prognostic factor B, absence of risk behavior, other treatments - "gold standard")
O = Outcome of interest (what result are you looking for? risk of disease, rate of occurrence of adverse outcomes like illness, comorbidity, or death)
T = Time (how long does it take to demonstrate an outcome? how long are participants observed? - if relevant to your question)
1. For healthcare organizations (P), does the adoption of a value-based care model (I) compared to maintaining a fee-for-service payment model (C) lead to improved patient outcomes (O)?
2. For patients visiting an outpatient specialty clinic (P), does the implementation of a patient-centered scheduling system (I) compared to traditional block scheduling methods (C) lead to reduced patient wait times (O)?
3. For front-desk staff at a multi-specialty outpatient clinic (P), does the implementation of a comprehensive customer service training program (I) compared to existing, unstandardized, and optional training (C) lead to improved patient satisfaction scores (O)?
Clinical Examples
1. P = menopausal women; I = cranberry juice; C = no cranberry juice; O = incidence of UTI
In menopausal women, does drinking 1 cup of cranberry juice daily versus not drinking any cranberry juice lower the incidence of urinary tract infections?
Initial keywords: menopause, cranberry juice, urinary tract infections
2. P = adults with arthritis; I = tomatoes; C = No comparison; O = increased joint pain
Do tomatoes worsen joint pain in adults with arthritis?
Initial keywords: tomatoes, arthritis, pain
Reference:
Godshall, M. (2016). Fast facts for evidence-based practice in nursing (2nd ed.). Springer Publishing Company. DOI 10.1891/9780826194077

Clinical Study: automatically includes Clinical Trial, Controlled Clinical Trial, Randomized Clinical Trial, Observational Study
Comparative Study = comparison of outcomes, results, etc. for different techniques, therapeutic approaches or other inputs.
Meta-Analysis = (multi-study) - studies using a quantitative method of combining the results of independent studies and synthesizing summaries and conclusions which may be used to evaluate therapeutic effectiveness.
Multicenter Study = a study conducted by several institutions
Systematic Reviews = (multi-study) - review of primary literature that attempts to identify, appraise, and synthesize all empirical evidence that meets specified eligibility criteria to answer a given research question. Systematic Reviews are NOT the same as Literature Reviews. Literature Reviews are NOT EBP.
Evaluation Study = studies determining the effectiveness of processes, personnel, and equipment
Validation Study = research using processes by which the reliability and relevance of a procedure for a specific purpose are established
Practice Guidelines: most are EBP, but some are still opinion-based. You will need to review the guideline to ensure it is EBP.
Epidemiologic Studies - Use for studies that examine associations, hypothesized causal relations. They are usually concerned with identifying or measuring the effects of risk factors or exposures.
Search term automatically includes: Cohort Studies, Longitudinal Studies, Prospective/Retrospective Studies, Case Control Studies, Cross Sectional Studies.
Qualitative Research - can also use the following search terms to capture the various types of qualitative studies:
Quasi-experimental designs - are ideal for healthcare administration and quality improvement research because they can evaluate a large-scale organizational change that can't be ethically or practically randomized. Can also use the following subject term
Interrupted time series (ITS) design - involves collecting data on key outcomes (e.g., average wait times) at multiple time points before and after the new protocol is implemented. This allows researchers to analyze trends and see if the intervention caused a significant change in the level of the outcomes. Can also use the following subject term
"Costs and Cost Analysis"[Mesh] - absolute, comparative, or differential costs pertaining to services, institutions, resources, etc., or the analysis and study of these costs.
Sample non-clinical study designs
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